What occurs when federal and state legislation conflict according to the Supremacy Clause?

The Supremacy Clause, which is found in Article VI, Clause 2 of the U.S. Constitution, establishes that the Constitution and federal laws made pursuant to it take precedence over state laws. When there is a conflict between federal and state legislation, the federal law will be enforced over the state law. This ensures a uniform legal framework across the country, preventing states from enacting conflicting regulations that could create confusion or inequality among citizens.

In practice, this means that if a state law contradicts federal law, the federal law prevails, and the state law may be invalidated or set aside. This principle is foundational to maintaining a cohesive legal system in the United States, ensuring that federal legislation is uniformly applied regardless of varying state laws.